CINECA IRIS Institutional Research Information System

CD133 structural instability as a gateway to medulloblastoma vulnerability

Background: Medulloblastoma (MB) is the most common malignant paediatric brain tumor. Among distinct MB subtypes, Group 3 represents one of the most aggressive subtypes, with high relapse rate, frequent metastasis, and mortality. These malignant traits are largely driven by MB stem cells (MBSCs), a subpopulation with enhanced self-renewal capacity and resistance to standard therapies, making them prime targets for innovative treatment strategies. Methods: Group 3 MB human cell lines were...

Carbohydrate- and heterocycle-based β-glucocerebrosidase inhibitors: State of the art and emerging relationship with cancer treatment

Overcoming drug resistance remains a significant challenge in cancer treatment. The enzyme β-glucocerebrosidase (GCase) plays several roles in cellular processes, including carbohydrate metabolism and the hydrolysis of glucosides. Aberrant GCase activity has been linked to various diseases, and recent studies have implicated it in cancer, where increased levels of GCase are frequently observed. This Review examines the relationship between GCase and cancer, emphasizing its potential as a ther...

Blockchain and Internet of Medical Things for Resilient Healthcare

Evaluation of Candida albicans and anaerobic bacterial co-expansion in vulvovaginal candidiasis: a cross-sectional study

Background – Vulvovaginal candidiasis (VVC) is a common mucosal infection predominantly attributed to Candida albicans (C. albicans). However, this yeast frequently colonizes the vaginal niche without causing symptoms, indicating that additional microbial and host factors might contribute to disease onset and/or pathology. This study investigated whether VVC is associated with a shift in the vaginal microbiota. Methods – Vaginal samples from 96 non-pregnant women were stratified into three st...