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Migranti adulti e apprendimento della Lingua Seconda per l’inclusione sociale. Indagine qualitativa sulle scuole di italiano L2 di Roma

A Fast and Furious Liquid Biopsy Assay to Monitor Targeted Therapy Resistance

Liquid biopsies represent a valid alternative to conventional tissue biopsies, offering a real time molecular picture of tumors in a minimally invasive manner. Of the various circulating biomarkers available for liquid biopsy, circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) are the most intensively studied to date. However, CTC and ctDNA represent different tumor components, therefore, complementary information from both sources might be beneficial. This protocol foc...

Functional outcomes of copy number variations of Chrna7 gene: Current knowledge and new insight from induced pluripotent stem cells studies

The discovery of genomic rearrangements, known as copy number variations (CNVs), is relatively new; their contribution to genetic heterogeneity and their impact on human diseases is still largely unknown. CNVs within the human 15q13.3 region have been associated with neuropsychiatric and neurodevelopmental disorders such as schizophrenia, autism spectrum disorders (ASD), intellectual disability, and epilepsy. Several recent studies suggest that, within this chromosomic region, the gene CHRNA7...

Induced pluripotent stem cells for modeling Smith-Magenis syndrome

Smith-Magenis syndrome (SMS) is a genetic neurodevelopmental disease characterized by neurological, psychiatric, anatomical, and motor symptoms. The disease is caused by deletions on chromosome 17p11.2, which may lead to the loss of up to 95 genes, depending on the length of the chromosomal rearrangement. One of these genes is retinoic acid-induced 1 (RAI1). Evidence that loss of RAI1 is responsible for several clinical manifestations of SMS came with the identification of patients carrying p...

Culturing and Expansion of “Clinical Grade” Neural Stem Cells from the Fetal Human Central Nervous System

NSCs have been demonstrated to be very useful in grafts into the mammalian central nervous system to investigate the exploitation of NSC for the therapy of neurodegenerative disorders in animal models of neurodegenerative diseases. To push cell therapy in CNS on stage of clinical application, it is necessary to establish a continuous and standardized, clinical grade (i.e., produced following the good manufacturing practice guidelines) human neural stem cell lines. In this chapter we will illu...

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