Exploring structure–activity relationships of pyrrolyl diketo acid derivatives as non-nucleoside inhibitors of terminal deoxynucleotidyl transferase enzyme

: Terminal deoxynucleotidyl transferase (TdT) is overexpressed in some cancer types, where it drives the mutagenic repair of double strand breaks through non canonical non-homologous end joining pathway. The TdT enzyme belongs to the X family of polymerases, together with the DNA polymerase λ (pol λ) and β (pol β). However, TdT exclusively displays template-independent nucleotide polymerisation. Pursuing our studies in developing TdT inhibitors, herein we deepened the structure-activity relat...

A multi-faceted stewardship perspective of the motives and mechanisms of sustainable value creation in family businesses

Framing European Youth Gender Attitudes through Serial Dramas: Focus Group Insights from the GEMINI Project

The wide universe of serial drama acts both as mirror and shaper of young adults’ perceptions and attitudes towards social issues, also fostering their growing interest in gender-related ones. Drawing from the European project GEMINI-Gender Equality through Media Investigation and New training Insights (CERV-2022-GE), this study provides the insights from the qualitative research phase, consisting of 15 focus groups interviews carried out in 4 countries (Denmark, Italy, Ireland and Romania) w...

Less Can Be More: Optimization of the Acquisition Range to Enhance Phasor Analysis in Fluorescence Lifetime Imaging Microscopy

The phasor approach is widely recognized as a powerful method for analyzing multidimensional images, and is currently one of the most utilized algorithms for spectral unmixing in fluorescence microscopy. Notably, it is exstensively employed in fluorescence lifetime imaging microscopy, but limitations in the acquisition window can affect the accuracy of lifetime and fraction estimates if not properly considered. In this article, we introduce a novel analytical framework to predict how photophy...