MALDI-TOF Clinical Filamentous Fungi Identification. Bead Beating Versus Acid Solvent Protein Extraction Method

In recent years, Matrix-Assisted Laser Desorption Ionization–Time-Of-Flight Mass Spectrometry (MALDI-TOF) has changed clinical microbiology, allowing filamentous fungi identification. The aim of this paper is to validate a novel protein extraction method using bead beating to identified filamentous fungi and compare the fingerprinting spectra obtain to acid solvent method. A total of 50 clinical isolates, including Trichophyton interdigitale, T.rubrum, T.tonsurans, Aspergillus terreus, Micros...

Epigenetic and Genetic Keys to Fight HPV-Related Cancers

Cervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving its carcinogenic potential. Despite extensive investigative efforts, numerous facets concerning HPV infection, replication, and pathogenesis remain shrouded in uncertainty. The virus operates through a variety of ...

Epidemiologyof Multi and Extensively Drug Resistance Pseudomonas Aeruginosa Infections from University Hospital “Luigi Vanvitelli” of Naples.

Chikungunya virus: Update on molecular biology, epidemiology and current strategies

Chikungunya virus (CHIKV), an arthropod-borne virus, is the aetiological agent of a disease characterized by several aspecific symptoms including fever, myalgia and arthralgia. The virus is primarily transmitted to humans through the bite of an infected mosquito of Aedes genus. This virus was first isolated in Tanzania in 1953, from which it spread to other African countries, Asia, Northern and Southern America, Europe and Oceania. Today, many human cases of CHIKV infection have been identifi...