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Organotropism-specific circulating tumor cells profiles: Morphology and heterotypic clustering predict metastatic sites in liquid biopsy of solid tumors

Background: While circulating tumor cells (CTCs) are the primary drivers of metastatic dissemination, the mechanisms governing their organotropism remain poorly characterized. CTC morphology, including size and elongation, and cluster configuration (homotypic vs. heterotypic) may encode site-specific metastatic signatures. Characterizing these features could provide critical pre-radiological biomarkers for predicting organ-specific recurrence and refining metastatic risk assessment in clinica...

Interactions Between Circulating Tumor Cells and the Immune System in Colorectal Cancer: Friends or Foes?

: Colorectal cancer (CRC) is a leading cause of cancer death worldwide, mainly due to metastasis. Circulating tumor cells (CTCs) act as the biological "seeds" of dissemination, traveling through the bloodstream to colonize distant organs. However, the blood is a hostile environment where CTCs must constantly face immune pressure. This review explores the bidirectional interactions between CTCs and immune cells in CRC, asking whether CTCs are merely vulnerable targets of immunosurveillance or ...

Treating tuberculosis without rifampicin: an open dilemma

Background: The World Health Organization recommends the same treatment regimens for rifampicin-monoresistant (RR) and multidrug-resistant (MDR) TB. Aside of resistance, rifampicin cannot be used in all patients because of allergy, intolerance or drug-to-drug interactions (here called “functional” rifampicin mono-resistance or fRR). Objectives: Given the uncertainty on the best way to treat these forms of TB, we performed a literature review assessing the epidemiology and diagnostic tools for...

Reproducibility of AI-generated antibiotic recommendations in standardised clinical scenarios: A proof-of-concept experimental study

Background Artificial intelligence (AI) tools are increasingly used to support antimicrobial prescribing, but most published literature focuses on accuracy rather than reproducibility across identical inputs. Reproducibility is a key requirement for safe clinical decision support. Methods We conducted a comparative experimental study assessing the reproducibility of outputs and the clinical correctness of antibiotic and treatment-duration recommendations generated by a general-purpose large l...

Cellulose-reinforced electrospun poly(ε-caprolactone)/poly(glycerol sebacate) composite fibers: Enhanced mechanical properties for Achilles tendon repair

Achilles tendon ruptures represent challenging clinical scenarios owing to high re-rupture rates commonly associated with biomaterials implantation and limited functional recovery. This leads to the need for mechanically enhanced scaffolds capable of withstanding demanding load-bearing requirements during healing and rehabilitation. This study investigated acetylated cellulose nanofibers (aCNFs) reinforcement of electrospun poly(ε-caprolactone)/poly(glycerol sebacate) (PCL/PGS) composite fibe...

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Prodotti recenti

Organotropism-specific circulating tumor cells profiles: Morphology and heterotypic clustering predict metastatic sites in liquid biopsy of solid tumors

Interactions Between Circulating Tumor Cells and the Immune System in Colorectal Cancer: Friends or Foes?

Treating tuberculosis without rifampicin: an open dilemma

Reproducibility of AI-generated antibiotic recommendations in standardised clinical scenarios: A proof-of-concept experimental study

Cellulose-reinforced electrospun poly(ε-caprolactone)/poly(glycerol sebacate) composite fibers: Enhanced mechanical properties for Achilles tendon repair

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