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Videogames for academic wellbeing: a biopsychosocial health psychology framework for university counseling and mental health promotion

In recent years, videogames have attracted growing attention not only for their recreational value, but also for their potential to foster personal and social identity, enhance cognitive functioning, and promote psychological wellbeing. Consistent with a biopsychosocial perspective on health, this paper conceptualizes gaming as a psychological, behavioral, and social resource that can be purposefully integrated into health-promotion practice, and explores its use within care contexts, with a ...

Indirect prompt injection in large language models

This paper addresses the emerging threat of indirect prompt injection, a technique in which malicious agents embed prompts into seemingly innocuous text to manipulate the behaviour and output of Generative Large Language Models (LLMs). As LLMs become more popular and commonly used in everyday activities, this type of attack poses serious concerns about their responses. Without knowledge and protection, processes that depend on them may not be reliable. We present and analyse real-world high-r...

Stress Detection from Multimodal Physiological Data Using Hybrid Deep Learning Models

Chronic stress and depression-adjacent emotional states affect over 970 million people worldwide, yet their continuous, objective detection from physiological signals remains unsolved, particularly when cues are subtle and conventional approaches fail. Single modality classifiers capture only part of the picture, and binary valence/arousal formulations collapse emotionally distinct states into the same category, leaving conditions like sadness and depression characterised by Low-Valence Low-A...

Mepolizumab effectiveness for patients with severe, uncontrolled chronic rhinosinusitis with nasal polyps in Italy (MEPOREAL): a real-life, multicentre, phase 4 trial

Background: Real-life data on mepolizumab in chronic rhinosinusitis with nasal polyps (CRSwNP) remain heterogeneous. This large, multicentre study aimed to evaluate mepolizumab effectiveness and safety in patients with severe, uncontrolled CRSwNP. Here, we present the results from the first 12-month treatment. Methods: This real-life, multicentre, ambispective, phase 4 study was conducted across 25 Italian tertiary referral rhinology clinics experienced in the management of severe, uncontroll...

Severe Chronic Rhinosinusitis with Nasal Polyps: From IL-5–Driven Pathogenetic Mechanisms to Clinical Management in the Italian Clinical Setting

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly debilitating airway disease primarily characterized by type 2 inflammation and eosinophilic infiltration. Among the key cytokines involved, Interleukin-5 (IL-5) plays a relevant role in eosinophil biology and contributes, together with other mediators of type 2 inflammation, to epithelial barrier dysfunction, immune dysregulation, mucus hypersecretion, and tissue remodeling. Therapies targeting this cytokine have demonstrated both ...

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