1 Contributo su Rivista

1 Contributo su Rivista: [13339] Home page macrotipologia

Sfoglia

Prodotti recenti

Investigational drugs in dry eye disease

Introduction: The dry eye disease (DED) is a chronic multifactorial disorder of the tears that also involves the ocular surface, the lacrimal glands, and meibomian dysfunction. Furthermore, DED is often associated with Sjögren's syndrome (SS) and other autoimmune disorders. Sometimes, this chronic or subclinical condition is difficult to diagnose and treat, due to its heterogeneity. Areas covered: A literature search of relevant publications about treatment of DED was performed. All relevant ...

Cenegermin for the treatment of neurotrophic keratitis

The trigeminal nerve provides corneal sensitivity and trophic supply to corneal tissues. The impairment of corneal innervation leads to development of neurotrophic keratitis (NK). NK is a rare, degenerative corneal disease characterized by corneal hypo/anesthesia and development of nonhealing corneal epithelial defects and ulcers. NK is a challenging condition with high medical need due to the lack of approved treatments that can restore corneal integrity. Current treatment of NK aims at stim...

Current and emerging treatment options for vernal keratoconjunctivitis

Introduction: Vernal keratoconjunctivitis (VKC) is a rare, chronic allergic disease affecting children in prepuberal age. The hallmark of VKC is the presence of conjunctival upper tarsal and/or limbal papillary reaction. Recurrences of inflammation are characterized by intense ocular symptoms of itching, redness and photophobia associated with corneal involvement ranging from punctuate keratitis to corneal shield ulcers with risk of visual impairment.Areas covered: The goals of VKC treatment ...

Analysis of the pathogenic factors and management of dry eye in ocular surface disorders

The tear film represents the interface between the eye and the environment. The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome. Despite having a multifactorial origin, the main risk factors are female gender and advanced age. Likewise, morphological changes in several glands and in the chemical composition of their secretions, such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly rele...

Understanding the pathogenesis of neurotrophic keratitis: the role of corneal nerves

Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by trigeminal nerve damage, which leads to loss of corneal sensitivity, corneal epithelium breakdown, and poor healing. Though extremely uncommon, NK is increasingly recognized for its characteristics as a distinct and well-defined clinical entity rather than a rare complication of various diseases that can disrupt trigeminal innervation. Indeed, the defining feature of NK is loss of corneal sensitivity, and its c...

Scopri

Accesso al fulltext

no fulltext13339

CINECA IRIS Institutional Research Information System