Cocaine is one of the most widely used drugs that, due to its molecular properties, causesvarious behavioral alterations, including sexual behavior. In vivo and in vitro studies conductedmainly in mammals have shown various disorders of sexual activity and morpho-functional dysfunctions of the gonads in both sexes. Although the modalities are still unclear, cocaine has beenshown to alter the cell cycle, induce apoptosis, and alter sperm motility. In females, this drug altersthe formation of the meiotic spindle as well as may obstruct the ovulation mechanism of matureoocytes. The data provided in this review, in addition to reviewing the current literature on the maineffects of cocaine on spermatogenesis and oogenesis mainly in mammals, will hopefully providea basic overview that may help and support further future studies on the molecular interaction ofcocaine and its metabolites with germ cells
Cocaine Effects on Reproductive Behavior and Fertility: An Overview
Mileo, Aldo;
2023-01-01
Abstract
Cocaine is one of the most widely used drugs that, due to its molecular properties, causesvarious behavioral alterations, including sexual behavior. In vivo and in vitro studies conductedmainly in mammals have shown various disorders of sexual activity and morpho-functional dysfunctions of the gonads in both sexes. Although the modalities are still unclear, cocaine has beenshown to alter the cell cycle, induce apoptosis, and alter sperm motility. In females, this drug altersthe formation of the meiotic spindle as well as may obstruct the ovulation mechanism of matureoocytes. The data provided in this review, in addition to reviewing the current literature on the maineffects of cocaine on spermatogenesis and oogenesis mainly in mammals, will hopefully providea basic overview that may help and support further future studies on the molecular interaction ofcocaine and its metabolites with germ cellsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
