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Chemotherapy induced painful peripheral neuropathy alters Schwann cell derived extracellular vesicles isolated from mouse peripheral nerves

Martellucci S.;
2025-01-01
2025
Inglese
Vecchitto M, Norimoto M, Funk K, Wang Z, Arai T, Martellucci S, Gonias SL, and Campana WM1.
ISEV 2025
International Society for Extracellular Vesicles (ISEV) 2025 Annual Meeting
https://isev2025.eventscribe.net/index.asp?posterTarget=730076
Comitato scientifico
Sì
April 23, 2025
Vienna
Internazionale
chemotherapy; peripheral neuropathy; schwann cells; extracellular vesicles; peripheral nerves
Chemotherapy induced painful peripheral neuropathy (CIPPN) is a deleterious side effect of taxanes, a class of chemotherapy drugs used to treat cancer. Paclitaxel (PTX) is a widely used chemotherapy agent that induces neuropathic pain in cancer patients. The mechanisms underlying PTX induced CIPPN are still not fully understood. Extracellular vesicles (EVs) are involved in cell-to-cell communication and may be a potential target in CIPPN. Herein, we show that Schwann cell (SC) derived EVs from peripheral nerve change in response PTX treatment. Further, EVs isolated from PTX treated mice elicit cell signaling responses in sensory neurons that are associated with pain.
none
info:eu-repo/semantics/conferenceObject
Vecchitto, M.; Norimoto, M.; Funk, K.; Wang, Z.; Arai, T.; Martellucci, S.; Gonias, S. L.; Campana, W. M.
275
4 Contributo in Atti di Convegno (Proceeding)::4.3 Poster
8
4.3 Poster
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14085/43822
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