Periodontics has evolved from a simplistic model to a more complex interplay between infectionand host response. Genetic factors have been a new addition to the list of risk factors for periodontaldiseases. The processes leading to destruction and regeneration of the destroyed tissuesare of great interest to both researchers and clinicians.The selective susceptibility of subjects for periodontitis has remained an enigma and wide varietiesof risk factors have been implicated for the manifestation and progression of periodontitis.Emerging pathway models suggest that gene-environment interactions are etiologically importantin disease pathogenesis. The current practical utility of genetic knowledge in periodontitis is limited.Allelic variants at multiple gene loci probably influence periodontitis susceptibility. Thepro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbialinfection and a major modulator of extracellular matrix catabolism and bone resorption, andpolymorphisms in the IL-1 gene cluster have been associated with an increased risk of developingsevere adult periodontitis.The aim of this study was to test if polymorphisms of genes of IL-1�+4845 and IL-1�+3954 were linkedwith periodontitis, in a case-control study population, delimited to a specific geographic area, inassociation with microbiological findings.The polymorphisms observed in IL-1�+4845 and IL-1�3954 single nucleotide polymorphisms (SNPs),was significantly different among the study groups (healthy controls, mild, moderate and severeperiodontitis with p<0.05, d.f.=1.We found a significant correlation between the severe form of periodontitis and the presence ofcomposite genotype (p < 0.05, d.f.=1, calculated among healthy vs. severe). Furthermore a statisticallysignificant association between the presence of bacteria and periodontitis was detected(p<0.05, d.f.=1). In the current investigation findings were concordant with literature observations.
Cytokine Gene polymorphisms associate with microbioloical agents in periodontal disease: our experience
BALLINI, ANDREA;
2014-01-01
Abstract
Periodontics has evolved from a simplistic model to a more complex interplay between infectionand host response. Genetic factors have been a new addition to the list of risk factors for periodontaldiseases. The processes leading to destruction and regeneration of the destroyed tissuesare of great interest to both researchers and clinicians.The selective susceptibility of subjects for periodontitis has remained an enigma and wide varietiesof risk factors have been implicated for the manifestation and progression of periodontitis.Emerging pathway models suggest that gene-environment interactions are etiologically importantin disease pathogenesis. The current practical utility of genetic knowledge in periodontitis is limited.Allelic variants at multiple gene loci probably influence periodontitis susceptibility. Thepro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbialinfection and a major modulator of extracellular matrix catabolism and bone resorption, andpolymorphisms in the IL-1 gene cluster have been associated with an increased risk of developingsevere adult periodontitis.The aim of this study was to test if polymorphisms of genes of IL-1�+4845 and IL-1�+3954 were linkedwith periodontitis, in a case-control study population, delimited to a specific geographic area, inassociation with microbiological findings.The polymorphisms observed in IL-1�+4845 and IL-1�3954 single nucleotide polymorphisms (SNPs),was significantly different among the study groups (healthy controls, mild, moderate and severeperiodontitis with p<0.05, d.f.=1.We found a significant correlation between the severe form of periodontitis and the presence ofcomposite genotype (p < 0.05, d.f.=1, calculated among healthy vs. severe). Furthermore a statisticallysignificant association between the presence of bacteria and periodontitis was detected(p<0.05, d.f.=1). In the current investigation findings were concordant with literature observations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
