Although numerous biomaterials are used for maxillarysinus-lift surgery, the ideal material for such procedures has notyet been identified. Both heterologous and alloplastic bone substituteshave a solely osteoconductive effect and lack the osteoinductiveproperties of the bone morphogenetic proteins typical ofautologous bone. Our group assessed a new alloplastic graft material,poly(lactic-co-glycolic) acid/hydroxyapatite (PLGA/HA),implanted in a human model of maxillary sinus-lift surgery. Forthis prospective, random, double-blind trial, we used deproteinizedbovine bone (DBB) as the comparison material. Radiographic bonevertical height and density were assessed at approximately 28 weeksafter grafting using cone-beam computed tomography. The verticaldimension of the regenerated bone was equivalent between the2 groups. The density of the bone regenerated using PLGA/HA wassignificantly lower than that obtained with DBB. Despite clinicalassessments demonstrating that PLGA/HA has sufficient characteristicsfor use in sinus-lift surgery, DBB provided greater bonedensity and an equivalent vertical dimension of grafted bone. Furtherstudies are needed to supplement the radiologic findings with histologicand micromorphometric examinations.
Radiographic Evaluation of Regenerated Bone Following Poly(Lactic-Co-Glycolic) Acid/Hydroxyapatite and Deproteinized Bovine Bone Graft in Sinus Lifting
LUCCHESE , ALESSANDRA
;
2013-01-01
Abstract
Although numerous biomaterials are used for maxillarysinus-lift surgery, the ideal material for such procedures has notyet been identified. Both heterologous and alloplastic bone substituteshave a solely osteoconductive effect and lack the osteoinductiveproperties of the bone morphogenetic proteins typical ofautologous bone. Our group assessed a new alloplastic graft material,poly(lactic-co-glycolic) acid/hydroxyapatite (PLGA/HA),implanted in a human model of maxillary sinus-lift surgery. Forthis prospective, random, double-blind trial, we used deproteinizedbovine bone (DBB) as the comparison material. Radiographic bonevertical height and density were assessed at approximately 28 weeksafter grafting using cone-beam computed tomography. The verticaldimension of the regenerated bone was equivalent between the2 groups. The density of the bone regenerated using PLGA/HA wassignificantly lower than that obtained with DBB. Despite clinicalassessments demonstrating that PLGA/HA has sufficient characteristicsfor use in sinus-lift surgery, DBB provided greater bonedensity and an equivalent vertical dimension of grafted bone. Furtherstudies are needed to supplement the radiologic findings with histologicand micromorphometric examinations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
