IMPACT OF ENDODONTIC TREATMENT ON SYSTEMIC OXIDATIVE STRESS IN CHRONIC APICAL PERIODONTITIS: A PROSPECTIVE STUDY

Introduction: Increased cardiovascular morbidity is one potential systemic effect of increased oxidizing species generation linked to reactive oral illnesses like chronic apical periodontitis (CAP). In order to determine if endodontic therapy may correct the imbalance in oxidative stress levels between participants with chronic periodontitis and healthy controls, we conducted a study. Materials and Methods: Patients were chosen at random from two groups of dental clinics and private research. The biological antioxidant potential (BAP) test on plasma samples and the reactive oxygen metabolites (d-ROMs) test were used to assess the levels of oxidative stress in both CAP patients and healthy controls. Prior to endodontic therapy, as well as 30, and 90 days following treatment, measurements were obtained. Results: At baseline, oxidative stress levels were considerably greater in CAP patients than in controls. Following treatment, CAP patients' d-ROMs values dropped and their BAP values rose before reaching normal levels ninety days later. Conclusions: This research shows that oxidative stress and CAP are positively correlated. Risky oxidative stress is experienced by CAP patients; nevertheless, this stress can be lessened with appropriate endodontic therapy, reestablishing oxidative equilibrium and lowering the likelihood of associated systemic illnesses.