Primitive colorectal tumours and metastases: A brief report on 31 females with stage iv disease

We analysed primary tumour in the colon, with particular attention to the rectum and to metastatic patterns identified by computed tomography, in a female with advanced disease. This was a retrospective study involving a sample of 91 patients, where only 31 women with stage IV disease according to RECIST criteria and histologically confirmed primary colon cancer (54.84% with only rectum cancer) were considered. Our study revealed that the most common secondary sites in these patients with primary colon cancer were the lungs (p-value<0.005) and liver (p-value < 0.005). Since the primary colon tumour was located in the rectum more frequently than in other parts of the colon (54.84% = 17/31), an investigation on secondary sites of metastases from CRC (colorectal cancer) was performed. The most common secondary sites of metastases from CRC were the lungs and liver. Univariate analysis showed a significant negative linear correlation between lungs and peritoneum (R = -0.733, p-value = 0.0008) and between lungs and regional lymph nodes (R = -0.708, p-value = 0.0015). On the other hand, there was a significant positive linear correlation between ovaries and small intestine (R = 0.850, p-value < 0.0001), ovaries and adrenal glands (R = 0.928, p-value < 0.0001), regional lymph nodes and peritoneum (R = 0.740, p-value = 0.0007) and between small intestine and adrenal glands (R = 0.758, p-value = 0.0004). Finally, multivariate analysis showed that the small intestine and adrenal glands were significant positive predictors of metastases to the ovaries compared to others.